Novocib K0709-04-2 | PRPP-S Assay Kit 磷酸核糖焦磷酸合成酶活性检测试剂盒

品名：PRPP-S Assay Kit

中文名称：磷酸核糖焦磷酸合成酶活性检测试剂盒

货号：K0709-04-2

规格：10 mL of reaction mixture (half 96-well plate)

品牌：Novocib

产品描述

Phosphoribosylpyrophosphate synthetase (PRS; EC 2.7.6.1), an essential enzyme for the purine salvage pathway, is encoded by PRPS1 gene. Several mutations in this gene associated with genetic disorders have been described leading to PRS superactivity . This condition is inherited in an X-linked pattern.

PRPS1 gene overactivity increases the production of normal PRPP synthetase 1 enzyme, which increases the availability of PRPP. Excessive amounts of purines are generated leading to an accumulation of uric acid, a waste product of purine breakdown, in the body. A buildup of uric acid can cause gout, which is a form of arthritis resulting from uric acid crystals in the joints. Affected individuals may also develop kidney or bladder stones formed from uric acid crystals.

PRECICE® PRPP-S Assay Kit is designed for continuous monitoring of PRPP synthesis. The assay is based on coupling of two recombinant enzymes: Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Inosine Monophosphate Dehydrogenase (IMPDH).