Novocib K0709-06-2 | Itp Ase Assay Kit 肌苷三磷酸焦磷酸酶活性检测试剂盒

品名：Itp Ase Assay Kit

中文名称：肌苷三磷酸焦磷酸酶活性检测试剂盒

货号：K0709-06-2

规格：10 mL of reaction mixture (half 96-well plate)

品牌：Novocib

产品描述

PRECICE® ITPase Assay kit provides the first non radioactive and continuous protocol for measurement of ITP pyrophosphatase activity (also known as inosine triphosphatase and inosine triphosphate pyrophosphohydrolase) in cellular lysates in a convenient 96-well plate format.

ITP pyrophosphatase, or ITPase (EC 3.6.1.19), is an intracellular enzyme that catalyzes the pyrophosphohydrolysis of ITP/dITP and xanthosine triphosphate to prevent unusual nucleoside triphosphates from accumulating in (deoxy) nucleoside triphosphate (d)NTP pools and being integrated into RNA and DNA.

This enzyme is encoded by the ITPA gene in mammals. Certain ITPA variants causing ITPase deficiency have been linked to adverse reactions to the immunosuppressive thiopurine drugs azathioprine and 6-mercaptopurine, and protection against ribavirin-induced anemia.