Peptides EP06244_1 | HCMV UL40 15-23 (HLA-E)

品名：HCMV UL40 15-23 (HLA-E)

货号：EP06244_1

规格：1 mg; 5 mg

品牌：Peptides.de

产品描述

HCMV UL40 15-23 with the amino acid sequence VMAPRTLIL is a linear peptidic epitope (epitope ID 69921) that is an important negative regulator of natural killer cell activity. The HCMV UL40 15-23 peptide is often used as positive control. HCMV UL40 15-23 is part of the immune evasion strategie of the Human Cytomegalovirus (HCMV). The virus downregulates HLA class Ia molecule expression in order to evade T cell recognition. However, a lack of surface HLA class Ia molecules triggers cytotoxicity of Natural Killer (NK) cells. To counteract this effect, the Cytomegalovirus promotes upregulation of HLA-E and provides the peptide HCMV UL40 15-23 (VMAPRTLIL), which mimics the leader sequence of HLA-Cw03 (VMAPRTLIL). When loaded onto HLA-E, this peptide conferres resistance to NK cell lysis via the CD94/NKG2A receptor.  HLA-E is presenting peptides derived from self-proteomic content and peptides of pathogenic origin. VMAPRTLIL is part of the following proteins of human origin: Major histocompatibility complex, class I, C (UniProt:A0A140T9M0, A0A140T9U0, A0A0G2JH50, A0A140T912 and A0A140T9Z4) HLA class I histocompatibility antigen C alpha chain (UniProt:Q53YP1, Q5RIP0) HLA class I antigen (UniProt:Q5QT33) Isoform 2 of HLA class I histocompatibility antigen, C alpha chain (UniProt:P10321-2) See also an example comparison of our prices with the prices of other peptide manufacturers.