| 产品名称 | Quartett C-P012/P-P012 | PIN cocktail AMACR/p63 (QR108 & QM006) |
|---|---|
| 目录号 | C-P012/P-P012 |
| 别名 | PIN cocktail AMACR/p63 |
| 外观 | 见COA |
| 分子量 | |
| CAS | |
| 溶解度 | |
| 存储条件 | 见COA |
| 保存时间 | 见COA |
| 备注1 | |
| 备注2 |
Quartett C-C031/P-C031 | CD31 (QR034)
品名：PIN cocktail AMACR/p63 (QR108 & QM006) | Recombinant rabbit monoclonal antibody & mouse monoclonal antibody
货号：C-P012/P-P012
品牌：Quartett
规格：0.1 ml; 0.5 ml; 1 ml; 3 ml; 7 ml; 15 ml
产品描述
| Application | IHC (FFPE) | Host | AMACR: Rabbit, p63: Mouse |
| Subclass | AMACR: IgG, p63: IgG2a/k | Dilution range | - |
| Cellular localization | AMACR: Cytoplasm, p63: Nucleus | Control | Prostate carcinoma |
| Immunogen | Synthetic peptide from human AMACR & p63 | ||
AMACR is an important enzyme for the b-oxidation of branched-chain fatty acids. High expression of the AMACR protein is found in prostate adenocarcinomas, but not in benign prostate diseases. AMACR expression is also detected in premalignant lesions of the prostate, such as prostatic intraepithelial neoplasia (PIN). The p63 protein, a homolog of the tumor suppressor p53, is highly expressed in the basal or precursor layer of many epithelial tissues. p63 is detected in the basal cells of the prostate in normal prostate glands and PIN. However, it is negative in prostate adenocarcinoma. Therefore, p63 is useful as a differential marker between benign prostate glands and adenocarcinomas (negative marker). The combination of AMACR and p63 can be extremely useful in the diagnosis of PIN and small-focus adenocarcinomas, especially in difficult cases and cases with limited tissue. AMACR stains the cytoplasm of prostate adenocarcinomas and PIN, while p63 stains the basal cell nuclei of PIN and benign prostate glands.
