| 产品名称 | Quartett C-N004/P-N004 | NKX2.2 (QR077) |
|---|---|
| 目录号 | C-N004/P-N004 |
| 别名 | NKX2.2 |
| 外观 | 见COA |
| 分子量 | |
| CAS | |
| 溶解度 | |
| 存储条件 | 见COA |
| 保存时间 | 见COA |
| 备注1 | |
| 备注2 |
Quartett C-C031/P-C031 | CD31 (QR034)
品名：NKX2.2 (QR077) | Recombinant monoclonal rabbit antibody
货号：C-N004/P-N004
品牌：Quartett
规格：0.1 ml; 0.5 ml; 1 ml; 3 ml; 7 ml; 15 ml
产品描述
| Application | IHC (FFPE) | Host | Rabbit |
| Subclass | IgG | Dilution range | 1:50 – 1:100 |
| Cellular localization | nucleus | Control | Ewing's sarcoma, pancreas |
| Immunogen | Synthetic peptide from human NKX2.2 | ||
NKX2.2 is a transcription factor that plays a critical role in controlling cell fate specification and differentiation in many tissues. In the developing central nervous system, this developmentally important transcription factor acts as a transcriptional repressor, controlling oligodendrocyte differentiation and myelin gene expression. The role of the various NKX2.2 structural domains in this process is unclear. NKX2.2 expression has been found in intestinal neuroendocrine tumors, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. Recently, the NKX2.2 protein was identified as a target of EWS-FLI-1, the Ewing sarcoma-specific fusion protein, and array-based gene expression analyses have shown that it is differentially upregulated in Ewing sarcomas. It acts as a valuable marker for Ewing sarcomas and helps in the differential diagnosis of small round cell tumors.
