| 产品名称 | Quartett C-B002 | Bcl6 (QR047) |
|---|---|
| 目录号 | C-B002 |
| 别名 | Bcl6 |
| 外观 | 见COA |
| 分子量 | |
| CAS | |
| 溶解度 | |
| 存储条件 | 见COA |
| 保存时间 | 见COA |
| 备注1 | |
| 备注2 |
Quartett C-C031/P-C031 | CD31 (QR034)
品名：Bcl6 (QR047) | Recombinant monoclonal rabbit antibody
货号：C-B002
品牌：Quartett
规格：0.1 ml; 0.5 ml; 1 ml; 3 ml; 7 ml; 15 ml
产品描述
| Application | IHC (FFPE) | Host | Rabbit |
| Subclass | IgG | Dilution range | 1:100 – 1:200 |
| Cellular localization | nucleus | Control | Tonsil, Lymph node, Diffuse large B-cell lymphoma |
| Immunogen | Synthetic peptide from human Bcl6 | ||
Bcl6 is a regulatory gene encoding a zinc finger protein. It plays a key role in germinal center (GC) formation and acts as a regulator of B lymphocyte growth and development by protecting GC B cells from DNA damage-induced apoptosis. Bcl6 is predominantly expressed in GC B cells. Surrounding mantle and marginal zone B cells, plasma cells, and B precursor cells are negative for Bcl6. The Bcl6 antibody detects GC cells in lymphoid follicles and a variety of lymphomas, including follicular lymphomas, diffuse large B-cell lymphomas (DLBCL), and Burkitt lymphomas. In contrast, Bcl6 is not expressed in hairy cell leukemias, mantle cell, or peripheral lymphomas. Bcl6 is not restricted to the B-cell lineage but has also been detected in anaplastic large cell lymphomas. In addition, Bcl6 is involved in the differentiation of the breast epithelium, which could play a possible role in carcinogenesis.
