| 产品名称 | Quartett C-I002 | IRTA1 (QM005) |
|---|---|
| 目录号 | C-I002 |
| 别名 | IRTA1 |
| 外观 | 见COA |
| 分子量 | |
| CAS | |
| 溶解度 | |
| 存储条件 | 见COA |
| 保存时间 | 见COA |
| 备注1 | |
| 备注2 |
| 目录号 | 规格 | 价格 | 库存状态 | |
| C-I002-01 | 0.1 ml concentrate | 询价 | 咨询 | |
| C-I002-05 | 0.5 ml concentrate | 询价 | 咨询 | |
Quartett C-C031/P-C031 | CD31 (QR034)
品名：IRTA1 (QM005) | Monoclonal mouse antibody
货号：C-I002
品牌：Quartett
规格：0.1 ml; 0.5 ml
产品描述
| Application | IHC (FFPE) | Host | Mouse |
| Subclass | IgG | Dilution range | 1:50 – 1:200 |
| Cellular localization | Membrane | Control | tonsil, marginal zone lymphoma |
| Immunogen | Synthetic peptide from human IRTA1 | ||
IRTA1 (Immunoglobulin superfamily Receptor Translocation-Associated 1), also known as Fc-receptor-like 4 (FCRL4) or CD307d, is a structural member of a family of immunoglobulin-like proteins that mediate the immune response of B cells. In normal lymphoid tissues, IRTA1 is expressed in benign monocytoid B cells, in some marginal zone cells, and in intraepithelial B cells. In lymphomas, it is expressed by tumor cells involved in lymphoepithelial lesions. In marginal lymphomas, marginal zone B cells selectively express IRTA1, both in non-neoplastic lymphoid tissues and in malignant lymphomas. This offers the possibility of accurately diagnosing marginal lymphomas with a commercially available antibody. The new anti-IRTA1 antibody clone QM005 has the same reactivity and specificity as the anti-IRTA1 antibody produced from the MUM2 clone. This was determined by analyzing a large number of biopsies of nodal and extranodal marginal zone lymphomas, as well as non-marginal zone lymphomas. Thus, a suitable anti-IRTA1 antibody is now available for the detection of marginal zone lymphomas in lymph nodes and at extranodal sites.
