Synthelis | S052 | Active regulator of SIRT1

品名：Active regulator of SIRT1(AROS)

货号：S052

规格：10µg, 20µg ,100 µg , 200 µg, 500 µg,bulk

品牌：Synthelis

产品描述

AROS is a direct active regulator of SIRT1, an NAD+-dependent deacetylase. The binding of AROS to the deacetylase upregulate SIRT1. AROS localizes in the nucleus and the cytoplasmic ribosomes. The nuclear protein AROS (also termed 40S ribosomal protein S19-binding protein 1) enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity. Depletion of AROS enhances p21 expression and increases both the G0/G1 population and apoptosis in response to DNA damage, whereas AROS overexpression improves cell survival.