品名：Seraseq® Tumor Mutation DNA Mix v2 AF 7 HC

货号：0710-0095

品牌：SeraCare 

Product Specifications

                                Gene List

AKTI             FGFR3              JAK2             PDGFRA 

APC              FLT3                 KIT                PIK3CA 

ATM             FOXL2              KRAS             PTEN 

BRAF            GNA11             MPL              RET 

CTNNB1       GNAQ         NCOA4-RET      SMAD4 

EGFR             GNAS              NPM1           TP53 

ERBB2           IDH1          NRAS/CSDE1     TPR-ALK

Details

The Seraseq Tumor Mutation DNA Mix v2 (AF7) HC is a multiplexed mixture of actionable biosynthetic 

DNA targets precisely blended with a single, well-characterized genomic background. This product is 

produced under rigorous design control and manufacturing practices to an allelic frequency of 7%, and 

is offered in a high concentration (HC) format at 25 ng/µL. Designed to assess the overall performance 

of your somatic mutation assay by next-generation sequencing (NGS), this unique product includes a wide 

range of single nucleotide variants (SNVs), insertion-deletion mutations (indels), and structural variants (SVs). 

Single-vial format for daily run use 

40 unique multiplexed variants across 28 genes (see table in Specifications tab) 

          20 SNVs 

          5 SNVs that are part of homopolymers 

          13 indels 

           2 SVs 

Mutation targets quantitated with digital PCR 

Well-characterized GM24385 human genomic DNA as background wild-type material 

Manufactured within cGMP-compliant, ISO 13485-certified facilities 

The Seraseq Tumor Mutation DNA Mix v2 (AF7) HC is formulated for use with targeted next-generation sequencing

 (NGS) assays that detect mutations in key oncogenes and tumor suppressor genes. 

The Seraseq Tumor Mutation DNA Mix v2 (AF7) HC is intended as a quality reference material for translational and 

disease research testing to monitor library preparation, sequencing, and variant allele detection under a given set 

of bioinformatics pipeline parameters. Previous Part Number: 0710-0073. 

For research use only. Not for use in diagnostic procedures. 

维百奥生物代理SeraCare对照及参比物质。

维百奥（北京）生物科技有限公司，自2018年与SeraCare（现隶属于LGC Clinical Diagnostics）合作以来，长期为中国客户

提供包括SeraSeq系列参比物质，领域包括肿瘤、生殖健康和遗传病。SeraCare研发和生产一系列临床参比物质，可以用于任何

研发阶段，以确保临床基因组学检测结果的准确性。

SeraCare参比物质涵盖的范围：

1）Next Generation Sequencing

2）Sanger Sequencing

3）Real-time PCR and digital PCR (dPCR)

4）Microarray

主要特点

1）Ready-to-use reference materials covering clinically-relevant variants and all variant types - SNVs, INDELS, CNVs, 

and RNA fusions

2）Highly multiplexed - provide significantly more data per NGS run, saving sequencing costs

3）Available in multiple formats to suite different workflow needs - purified DNA & RNA, ctDNA, encapsulated ctDNA 

in plasma, and FFPE

4）Manufactured in cGMP-compliant, ISO 13485-certified facilities

5）Stringent product release testing - all variants qualified by dPCR for allele frequencies or copy numbers