品名：Seraseq® Tri-Level Tumor Mutation DNA Mix v2 HC

货号：0710-0097

品牌：SeraCare 

Product Specifications

AKTI         FGFR3        JAK2                 PDGFRA 

APC          FLT3           KIT                    PIK3CA 

ATM         FOXL2        KRAS                PTEN 

BRAF        GNA11       MPL                 RET 

CTNNB1   GNAQ        NCOA4-RET     SMAD4 

EGFR        GNAS         NPM1               TP53 

ERBB2      IDH1          NRAS/CSDE1    TPR-ALK

Details

The Seraseq Tri-Level Tumor Mutation DNA Mix v2 (HC) is a multiplexed mixture of actionable biosynthetic DNA 

targets precisely blended with a single, well-characterized genomic background. This product is produced under 

rigorous design control and manufacturing practices, offered in a high concentration (HC) format at 25 ng/µL. 

Designed to assess the overall performance of your somatic mutation assay by next-generation sequencing (NGS), 

this unique product offers a range of allele frequencies in a single sample format, including single nucleotide 

variants (SNVs), insertion-deletion mutations (indels), and structural variants (SVs). 

Single-sample format for daily run use 

40 unique multiplexed variants across 28 genes (see table in Specifications tab) at allele frequencies distributed 

at 4%, 7% or 10% 

      20 SNVs 

      5 SNVs that are part of homopolymers 

     13 indels 

      2 SVs 

Mutation targets quantitated with digital PCR 

Well-characterized GM24385 human genomic DNA as background ‘wild-type’ material 

Manufactured under cGMP within ISO 9001 and ISO 13485 certified facilities 

The Seraseq Tri-Level Tumor Mutation DNA Mix v2 (HC) is formulated for use with targeted next-generation sequencin

(NGS) assays that detect mutations in key oncogenes and tumor suppressor genes. The Seraseq Tri-Level Mutation 

DNA Mix v2 (HC) is intended as a quality reference material for translational and disease research testing to monitor 

library preparation, sequencing, and variant allele detection under a given set of bioinformatics pipeline parameters. 

For research use only. Not for use in diagnostic procedures. 

维百奥生物代理SeraCare对照及参比物质。

维百奥（北京）生物科技有限公司，自2018年与SeraCare（现隶属于LGC Clinical Diagnostics）合作以来，长期为中国客户

提供包括SeraSeq系列参比物质，领域包括肿瘤、生殖健康和遗传病。SeraCare研发和生产一系列临床参比物质，可以用于任何

研发阶段，以确保临床基因组学检测结果的准确性。

SeraCare参比物质涵盖的范围：

1）Next Generation Sequencing

2）Sanger Sequencing

3）Real-time PCR and digital PCR (dPCR)

4）Microarray

主要特点

1）Ready-to-use reference materials covering clinically-relevant variants and all variant types - SNVs, INDELS, CNVs, 

and RNA fusions

2）Highly multiplexed - provide significantly more data per NGS run, saving sequencing costs

3）Available in multiple formats to suite different workflow needs - purified DNA & RNA, ctDNA, encapsulated ctDNA 

in plasma, and FFPE

4）Manufactured in cGMP-compliant, ISO 13485-certified facilities

5）Stringent product release testing - all variants qualified by dPCR for allele frequencies or copy numbers