品名：Seraseq® Lung & Brain CNV Mix, + 3 copies

货号：0710-0414

品牌：SeraCare 

Product Specifications 

# of CNVs：3 (full gene region for EGFR, MYCN, and MET) 

Copy Numbers：+3 copies (or 5 total copies) of each gene 

Concentration：10 ng/µL Amount 200 ng (single vial) 

Buffer：1 mM Tris / 0.1 mM EDTA pH 8.0 

Also Available: 

Seraseq™ Lung & Brain CNV Mix, + 6 copies 

Seraseq™ Lung & Brain CNV Mix, + 12 copies

Details

Copy number variations (CNV) are genomic changes that lead to higher (amplification) or lower (loss) gene copies 

in comparison to a reference genome. Cells that are affected by aberrant copy number changes for certain 

cancer-associated genes may experience disruption of normal cellular function and, ultimately, tumorigenesis. 

Next-generation sequencing (NGS) can be used to determine CNVs across multiple genes in a sequencing run. 

However, without a widely adopted standard for CNV profiling, NGS assays may evaluate dosage for different 

targets using different wet and dry methods. In response, SeraCare has developed the first disease-specific CNV

reference materials to support clinical labs performing NGS-based tumor profiling of lung and brain cancer 

patient samples. 

Single sample with three clinically-relevant CNVs (save acquisition and sequencing costs) 

Develop, optimize, and validate your assay’s ability to detect a range of copy numbers (amplifications) 

CNV targets precisely quantitated with digital PCR 

Single well-characterized GM24385 human genomic DNA as background wild-type material 

Manufactured in GMP-compliant, ISO 13485-certified facilities 

This specific CNV Mix for lung and brain cancer includes 3 copies. 

维百奥生物代理SeraCare对照及参比物质。

维百奥（北京）生物科技有限公司，自2018年与SeraCare（现隶属于LGC Clinical Diagnostics）合作以来，长期为中国客户

提供包括SeraSeq系列参比物质，领域包括肿瘤、生殖健康和遗传病。SeraCare研发和生产一系列临床参比物质，可以用于任何

研发阶段，以确保临床基因组学检测结果的准确性。

SeraCare参比物质涵盖的范围：

1）Next Generation Sequencing

2）Sanger Sequencing

3）Real-time PCR and digital PCR (dPCR)

4）Microarray

主要特点

1）Ready-to-use reference materials covering clinically-relevant variants and all variant types - SNVs, INDELS, CNVs, 

and RNA fusions

2）Highly multiplexed - provide significantly more data per NGS run, saving sequencing costs

3）Available in multiple formats to suite different workflow needs - purified DNA & RNA, ctDNA, encapsulated ctDNA 

in plasma, and FFPE

4）Manufactured in cGMP-compliant, ISO 13485-certified facilities

5）Stringent product release testing - all variants qualified by dPCR for allele frequencies or copy numbers