品名：Seraseq® HRD gDNA Negative Mix 

货号：0710-2881

品牌：SeraCare 

Product Specifications - gDNA HRD Negative Mix 

GIS#：33 

Number of genes：4(ATM,BRIPRAD51CRAD51D) 

Number of variants：8(4 SNVs,3 insertions,1 deletion) 

Format：gDNA 

Size：2x 500 ng(25 ng/ul; tumor and normalmatched 

#Genomic Instability Score (GIS) calculated using Illumina TruSight™ Oncology (TSO) 500 HRD RUO assay which 

calculates a GIS using an algorithm licensed from Myriad Genetics. Illumina TSO 500 HRD is not available in Japan.

Details

Genomic instability resulting from homologous recombination DNA repair deficiency (HRD) is a response biomarker 

to assess ovarian and breast cancer patient eligibility for PARP inhibitor and platinum-based therapies. HRD 

measurements have the potential to improve cancer therapy, however standardizing and democratizing HRD 

measurements remains challenging due to their inherent complexity. This cell line-derived HRD reference material 

can support the development, validation, and routine use of assays determining HRD status in cancer patients. 

FEATURES 

Derived from tumor and matched-normal human cell lines 

Allows blending to desired % tumor content with included SNP-matched normal cell line gDNA 

20 µL of both tumor and matched normal gDNA at 25 ng/µL Additional biosynthetic single-nucleotide variants 

(SNVs) of 4 

homologous recombination repair (HRR) genes 

HRD status validated by targeted Next Generation Sequencing (NGS) 

Manufactured in GMP-compliant, ISO 13485-certified facilities 

维百奥生物代理SeraCare对照及参比物质。

维百奥（北京）生物科技有限公司，自2018年与SeraCare（现隶属于LGC Clinical Diagnostics）合作以来，长期为中国客户

提供包括SeraSeq系列参比物质，领域包括肿瘤、生殖健康和遗传病。SeraCare研发和生产一系列临床参比物质，可以用于任何

研发阶段，以确保临床基因组学检测结果的准确性。

SeraCare参比物质涵盖的范围：

1）Next Generation Sequencing

2）Sanger Sequencing

3）Real-time PCR and digital PCR (dPCR)

4）Microarray

主要特点

1）Ready-to-use reference materials covering clinically-relevant variants and all variant types - SNVs, INDELS, CNVs, 

and RNA fusions

2）Highly multiplexed - provide significantly more data per NGS run, saving sequencing costs

3）Available in multiple formats to suite different workflow needs - purified DNA & RNA, ctDNA, encapsulated ctDNA 

in plasma, and FFPE

4）Manufactured in cGMP-compliant, ISO 13485-certified facilities

5）Stringent product release testing - all variants qualified by dPCR for allele frequencies or copy numbers