产品名称 | Seraseq® HRD gDNA High-Positive Mix (SeraCare) |
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目录号 | 0710-2879 |
别名 | N/A |
外观 | N/A |
分子量 | N/A |
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溶解度 | N/A |
存储条件 | N/A |
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目录号 | 规格 | 价格 | 库存状态 | |
0710-2879 | 2 x 20 µl | 咨询客服 | 咨询客服 |
品名:Seraseq® HRD gDNA High-Positive Mix
货号:0710-2879
品牌:SeraCare
Product Specifications - gDNA HRD High-Positive Mix
GIS#:72
Number of genes:4(ATMBRIPRAD51CRAD51D)
Number of variants:8(4 SNVs,3 insertions,1 deletion)
Format:gDNA
Size:2 x500 ng(25 ng/ul; tumor and normal matched)
#Genomic Instability Score (GIS) calculated using llumina TruSight" Oncology (TSO) 500 HRD RUO assaywhich
calculates a GlS using an algorithm licensed from Myriad Genetics, lumina TSO 500 HRD is notavailable in Japan.
Details
Genomic instability resulting from homologous recombination DNA repair deficiency (HRD) is a response
biomarker to assess ovarian and breast cancer patient eligibility for PARP inhibitor and platinum-based
therapies. HRD measurements have the potential to improve cancer therapy, however standardizing and
democratizing HRD measurements remains challenging due to their inherent complexity. This cell
line-derived HRD reference material can support the development, validation, and routine use of assays
determining HRD status in cancer patients.
FEATURES
Derived from tumor and matched-normal human cell lines
Allows blending to desired % tumor content with included SNP-matched normal cell line gDNA
20 µL of both tumor and matched normal gDNA at 25 ng/µL
Additional biosynthetic single-nucleotide variants (SNVs) of 4 homologous recombination repair (HRR) genes
HRD status validated by targeted Next Generation Sequencing (NGS)
Manufactured in GMP-compliant, ISO 13485-certified facilities
维百奥生物代理SeraCare对照及参比物质。
维百奥(北京)生物科技有限公司,自2018年与SeraCare(现隶属于LGC Clinical Diagnostics)合作以来,长期为中国客户
提供包括SeraSeq系列参比物质,领域包括肿瘤、生殖健康和遗传病。SeraCare研发和生产一系列临床参比物质,可以用于任何
研发阶段,以确保临床基因组学检测结果的准确性。
SeraCare参比物质涵盖的范围:
1)Next Generation Sequencing
2)Sanger Sequencing
3)Real-time PCR and digital PCR (dPCR)
4)Microarray
主要特点
1)Ready-to-use reference materials covering clinically-relevant variants and all variant types - SNVs, INDELS, CNVs,
and RNA fusions
2)Highly multiplexed - provide significantly more data per NGS run, saving sequencing costs
3)Available in multiple formats to suite different workflow needs - purified DNA & RNA, ctDNA, encapsulated ctDNA
in plasma, and FFPE
4)Manufactured in cGMP-compliant, ISO 13485-certified facilities
5)Stringent product release testing - all variants qualified by dPCR for allele frequencies or copy numbers