维百奥(北京)生物科技有限公司

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产品名称 Seraseq® HRD gDNA High-Positive Mix (SeraCare)
目录号 0710-2879
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目录号 规格 价格 库存状态  
0710-2879 2 x 20 µl 咨询客服 咨询客服

品名:Seraseq® HRD gDNA High-Positive Mix

货号:0710-2879 

品牌:SeraCare 


Product Specifications - gDNA HRD High-Positive Mix 

GIS#:72 

Number of genes:4(ATMBRIPRAD51CRAD51D) 

Number of variants:8(4 SNVs,3 insertions,1 deletion) 

Format:gDNA 

Size:2 x500 ng(25 ng/ul; tumor and normal matched) 


#Genomic Instability Score (GIS) calculated using llumina TruSight" Oncology (TSO) 500 HRD RUO assaywhich 

calculates a GlS using an algorithm licensed from Myriad Genetics, lumina TSO 500 HRD is notavailable in Japan.


Details

Genomic instability resulting from homologous recombination DNA repair deficiency (HRD) is a response 

biomarker to assess ovarian and breast cancer patient eligibility for PARP inhibitor and platinum-based 

therapies. HRD measurements have the potential to improve cancer therapy, however standardizing and 

democratizing HRD measurements remains challenging due to their inherent complexity. This cell 

line-derived HRD reference material can support the development, validation, and routine use of assays 

determining HRD status in cancer patients. 


FEATURES 


Derived from tumor and matched-normal human cell lines 

Allows blending to desired % tumor content with included SNP-matched normal cell line gDNA 

20 µL of both tumor and matched normal gDNA at 25 ng/µL 

Additional biosynthetic single-nucleotide variants (SNVs) of 4 homologous recombination repair (HRR) genes 

HRD status validated by targeted Next Generation Sequencing (NGS) 

Manufactured in GMP-compliant, ISO 13485-certified facilities 


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维百奥生物代理SeraCare对照及参比物质。


维百奥(北京)生物科技有限公司,自2018年与SeraCare(现隶属于LGC Clinical Diagnostics)合作以来,长期为中国客户

提供包括SeraSeq系列参比物质,领域包括肿瘤、生殖健康遗传病。SeraCare研发和生产一系列临床参比物质,可以用于任何

研发阶段,以确保临床基因组学检测结果的准确性。

 

SeraCare参比物质涵盖的范围:

1)Next Generation Sequencing

2)Sanger Sequencing

3)Real-time PCR and digital PCR (dPCR)

4)Microarray

 

主要特点

1)Ready-to-use reference materials covering clinically-relevant variants and all variant types - SNVs, INDELS, CNVs, 

and RNA fusions

2)Highly multiplexed - provide significantly more data per NGS run, saving sequencing costs

3)Available in multiple formats to suite different workflow needs - purified DNA & RNA, ctDNA, encapsulated ctDNA 

in plasma, and FFPE

4)Manufactured in cGMP-compliant, ISO 13485-certified facilities

5)Stringent product release testing - all variants qualified by dPCR for allele frequencies or copy numbers

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