品名：Seraseq® ctDNA Reference Material v2 AF1%

货号：0710-0204

品牌：SeraCare 

Product Specifications 

# of Variants 40 

Allele Frequency 1% 

Fragment Size ~170bp average 

 Concentration 25 ng/mL 

Volume 5 mL 

Total DNA 125 ng (single vial) 

Matrix SeraCon™ Matribase (human plasma-like) 

Archer® is a registered trademark, and Reveal ctDNA™ is a trademark of ArcherDx, Inc. 

Oncomine® is a registered trademark of Thermo Fisher Scientific. 

Details

To overcome the lack of patient-like reference materials for liquid biopsy, including drawbacks of existing 

methodologies such as sonication, SeraCare has developed a breakthrough technology that produces the 

most patient-like materials compared to native ctDNA. The Seraseq ctDNA Mutation Mix v2 is a highly 

multiplexed product for NGS-based ctDNA assays targeting cancer-relevant somatic mutations. 

This specific ctDNA Reference Material v2 product has an allele frequency of 1%. 

       Size distribution, library yield and complexity consistent with native ctDNA 

       Single sample with 40 clinically-relevant mutations across 28 genes, all at the same specified allele frequency 

       Offered in a full-process plasma-like material capable of assessing the entire workflow from extraction 

through analysis 

       Mutation targets precisely quantitated with digital PCR

       Single well-characterized GM24385 human genomic DNA as background wild-type material 

       Manufactured in GMP-compliant and ISO 13485-certified facilities

维百奥生物代理SeraCare对照及参比物质。

维百奥（北京）生物科技有限公司，自2018年与SeraCare（现隶属于LGC Clinical Diagnostics）合作以来，长期为中国客户

提供包括SeraSeq系列参比物质，领域包括肿瘤、生殖健康和遗传病。SeraCare研发和生产一系列临床参比物质，可以用于任何

研发阶段，以确保临床基因组学检测结果的准确性。

SeraCare参比物质涵盖的范围：

1）Next Generation Sequencing

2）Sanger Sequencing

3）Real-time PCR and digital PCR (dPCR)

4）Microarray

主要特点

1）Ready-to-use reference materials covering clinically-relevant variants and all variant types - SNVs, INDELS, CNVs, 

and RNA fusions

2）Highly multiplexed - provide significantly more data per NGS run, saving sequencing costs

3）Available in multiple formats to suite different workflow needs - purified DNA & RNA, ctDNA, encapsulated ctDNA 

in plasma, and FFPE

4）Manufactured in cGMP-compliant, ISO 13485-certified facilities

5）Stringent product release testing - all variants qualified by dPCR for allele frequencies or copy numbers