【产品概况】
产品名称:Human Integrin a4b7 (ITGA4 & ITGB7) Antibody (Vedolizumab, Research Use)
产品编号:NBR-0922
针对靶点:Integrin a4b7 (ITGA4 & ITGB7)
抗体药商品名:Vedolizumab
抗体药描述:Vedolizumab is a type of drug calleda monoclonal antibody. lt is used totreat inflammatory bowel disease(IBD), including ulcerative colitis andCrohn's disease. Vedolizumab is atargeted therapy that was designed tobe a gut-selective immunotherapy.
【产品参数】
产品外观:Transparent Liquid
分子量:~150kDa
CAS:N/A
溶解度:Water; PBS, TBS Buffer等
表达系统:CHO Expressed
抗体亚型:Ab. Isotype - IgG
【基因信息】
Gene Name: ITGA4 & ITGB7
Synonyms: CD49D
Target Description: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1.
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract.
Ensembl: ENSG00000115232; ENSG00000139626
Uniprot: P13612; P26010