【产品概况】
产品名称:Human TIGIT Antibody (Vibostolimab, Research Use)
产品编号:NBR-0924
针对靶点:TIGIT
抗体药商品名:Vibostolimab
抗体药描述:Vibostolimab is an anti-TIGIT therapy discovered and developed by Merck. Vibostolimab binds to TIGIT and blocks the interaction between TIGIT and its ligands (CD112 and CD155), thereby activating T lymphocytes which help to destroy tumor cells.
【产品参数】
产品外观:Transparent Liquid
分子量:~150kDa
CAS:N/A
溶解度:Water; PBS, TBS Buffer等
表达系统:CHO Expressed
抗体亚型:Ab. Isotype - IgG
【基因信息】
Gene Name: TIGIT
Synonyms: VSIG9; VSTM3
Target Description: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Ensembl: ENSG00000181847
Uniprot: Q495A1