Proteus BioSciences | DA13-10001 | 6-Monoacetylmorphine (6-MAM)-BSA Antigen, Antigen

品名：6-Monoacetylmorphine (6-MAM)-BSA Antigen, Antigen

货号：DA13-10001

品牌：Proteus BioSciences

产品描述

6-MAM occurs as a metabolite of heroin. Once it has passed first-pass metabolism, 6-MAM is then metabolized into morphine or excreted in urine. Heroin is rapidly metabolized by esterase enzymes in the brain and has an extremely short half-life. It has also relatively weak affinity to μ-opioid receptors because the 3-hydroxy group, essential for effective binding to the receptor, is masked by the acetyl group. Therefore, heroin acts as a pro-drug, serving as a lipophilic transporter for the systemic delivery of morphine, which actively binds with μ-opioid receptors.[1][2] Black tar heroin 6-MAM already has a free 3-hydroxy group and shares the high lipophilicity of heroin, so it penetrates the brain just as quickly and does not need to be deacetylated at the 6-position in order to be bioactivated; this makes 6-MAM somewhat more potent than heroin.

SPECIES CROSS-REACTIVITY:-

APPLICATIONS/DILUTIONS:Lateral Flow

SOURCE:chemical synthesis

FORM/STORAGE: Distilled water，Short term storage (≤ 2 weeks): 2–8 °C. Long term: -20 °C. Avoid repeated freezing and thawing.