Ubiqbio | UbiQ-115 | Biotin-K63 diUb-VME

品名：Biotin-K63 diUb-VME

货号：UbiQ-115

规格：50 µg

品牌：Ubiqbio

产品描述

activity-based probe for deubiquitinating enzymes (DUBs) based on K63 linked diUb, labeled with biotin on the N-terminus

UbiQ-115 is an activity-based probe for deubiquitinating enzymes (DUBs) based on K63 linked diUb. Here Lys63 has been replaced by a diaminobutyric acid residue equipped with a vinyl methyl amide warhead – the Dab(VME) type of structure is a DUB reactive mimic of the native isopeptidic linked Lys(Gly) residue. DUB activity based probe can be used for DUB activity profiling experiments and structural studies. The native distance between the proximal and distal Ub is preserved as much as possible in UbiQ-115. The N-terminus of the distal Ub is labeled with biotin; an aminohexanoic acid (Ahx) linker creates extra space for efficient access of biotin binding entities.

Applications: Crystallization, Pull down, Purification, Western Blot, Phenotypic protein profiling

Category: activity-based probes