Ubiqbio | UbiQ-188 | Biotin-Ahx-Ub-VS

品名：Biotin-Ahx-Ub-VS

货号：UbiQ-188

规格：50 µg

品牌：Ubiqbio

产品描述

a potent and specific inhibitor of deubiquitinating enzymes (DUBs), labeled with biotin on the N-terminus

Biotin-Ahx-Ub-VS (UbiQ-188) is a potent and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic vinyl sulfone (VS) group. UbiQ-188 can be used for activity profiling experiments and determining DUB inhibitor specificity. It is labeled on the N-terminus with a biotin and an aminohexanoic acid (Ahx) linker is introduced to create extra space between the biotin and Ub protein for efficient access of biotin binding entities. To eliminate Met1 oxidation, Met1 is replaced by norleucine, a well validated Met mimic.

Applications: Crystallization, Purification, Western Blot, Phenotypic protein profiling, DUB activity profiling

Category: activity-based probes