Ubiqbio | UbiQ-218 | HA-Ahx-Ahx-Ub-VPE

品名：HA-Ahx-Ahx-Ub-VPE

货号：UbiQ-218

规格：50 µg

品牌：Ubiqbio

产品描述

an activity-based probe for deubiquitinating enzymes (DUBs), labeled with HA on the N-terminus

HA-Ahx-Ahx-Ub-VPE (UbiQ-218) is an activity-based probe for deubiquitinating enzymes (DUBs). It is labelled on the N-terminus with the HA peptide sequence (YPYDVPDYA) derived from the influenza hemagglutinin protein and allows for the sensitive identification or purification of DUBs by anti-HA antibodies and/or anti-HA-agarose. The HA tag is separated from the N-terminus by two 6-aminohexanoic acid (Ahx) linkers for efficient recognition of the tag. The alkyne group in the vinyl pentynyl ester warhead allows for further (post-labelling) modification by using click chemistry.

Applications: Crystallization, Pull down, Purification, Western Blot, MS, NMR, Phenotypic protein profiling, DUB activity profiling, Compound library screening, Target inhibitor profiling

Category: activity-based probes