Ubiqbio | UbiQ-262 | Ac-ISG15prox-VPS

品名：Ac-ISG15prox-VPS

货号：UbiQ-262

规格：50 µg

品牌：Ubiqbio

产品描述

a potent, irreversible and specific activity-based probe for ISG15 proteases

UbiQ-262 is a potent, irreversible and specific activity-based probe for ISG15 proteases. It is prepared by total chemical synthesis and based on the proximal part of mouse ISG15. To improve stability, Cys77 and Cys144 are replaced by Ser. It contains a C-terminal vinyl pentynyl sulfone (VPS) electrophile which allows for post-labeling modification of cross-linked [UbiQ-237]::[ISG15 protease] complexes by using click chemistry with for example biotin-azide.

Applications: Crystallization, Pull down, Purification, Western Blot, MS, NMR, Phenotypic protein profiling, DUB activity profiling, Compound library screening, Target inhibitor profiling

Category: activity-based probes