品名: ISRI

货号: BN-1539-1

规格: 5mg

品牌：rPeptide

储存温度：-20℃

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描述：Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM[1]. Enhances spatial and fear-associated learning in mice and enhances cognitive function1,[2]. Mechanism of action involves activation of eiF2β[3]. Suppresses ER stress-induced inflammatory gene expression[4]. Potently attenuates amyloid β-induced neuronal cell death (1[2].5-25 nM) with no effect on amyloid β production[5]. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models[6].

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