Dharmacon has expanded its research tools across the full RNA interference (RNAi) workflow—covering siRNA, lentiviral shRNA, and microRNA research tools—along with genome-scale RNAi libraries for functional screening of genes, microRNAs, and long non-coding RNAs. In overexpression studies, Dharmacon offers one of the largest commercially available cDNA and ORF collections. Building on strengths in RNA synthesis chemistry and vector biology, Dharmacon also provides a comprehensive CRISPR-Cas9 genome engineering toolbox, including ready-to-use synthetic and lentiviral gRNA formats and Cas9 reagents to simplify tool selection across applications. 

Dharmacon has been assessed and holds ISO 9001:2008 certification for the design and manufacture of RNA, DNA, and viral products for research and laboratory use (including RNAi, gene expression, and gene editing).

■ Product Portfolio

Vicbio Biotechnology Co., Ltd. provides the full range of Dharmacon products.

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● siRNA: Proprietary duplex modification chemistry supports high specificity and potency. Accell™ siRNA enables delivery to difficult-to-transfect cells without transfection reagents, and specialized solutions are available for effective knockdown of lncRNA targets.

● shRNA: microRNA-adapted shRNA formats enable transient, constitutive, or inducible RNAi with durable long-term silencing, with multiple promoter options to optimize expression across cell types.

● microRNA: Modulate endogenous microRNA function using microRNA mimics (upregulation) or hairpin inhibitors (inhibition).

● cDNA & ORF Collections: From genome-scale libraries to individual clones, Dharmacon provides one of the industry’s largest clone collections.

● Custom RNA Synthesis: High-quality custom single-strand RNA, siRNA, and microRNA synthesis with broad modification options, synthesis scales, and purification choices.

● RNAi Screening Libraries: Choose from siRNA, shRNA, and microRNA libraries ranging from gene-family sets to whole-genome coverage, or build custom “Cherry-Pick” libraries by selecting targets, formats, and quantities.

● Gene Editing (CRISPR-Cas9): A streamlined CRISPR-Cas9 platform for mammalian gene editing with ready-to-use reagents and broad applicability. Predesigned genome-wide guide RNA sets (human/mouse/rat) are available based on the Edit-R design approach.

● DharmaFECT™ Transfection & Ancillary Reagents: Transfection reagents, buffers, and supporting reagents optimized for efficient, low-toxicity delivery of RNAi and CRISPR reagents—from single-gene experiments to genome-wide screens.

■ Product List