Tymora Analytical is dedicated to providing contract services and innovative products for diagnostic development and exosome proteomics, supporting advancements in cancer research.The company’s core mission is to facilitate the transition from traditional tissue biopsy to liquid biopsy, while pioneering innovations in phosphoproteomics and extracellular vesicle (EV) analysis.Through its proprietary technologies, Tymora Analytical enables the direct detection of biologically active exosomal proteins and phosphorylated protein cancer biomarkers from biological fluids such as plasma, urine, and saliva.As a platform for biomarker discovery, validation, and routine diagnostic testing, Tymora’s unique approach offers significant potential for identifying previously inaccessible signaling proteins in complex biological fluids, opening new possibilities for disease diagnostics and biomarker research.

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●pIMAGO™ — Universal Antibody-Free Phosphoprotein Detection Technology

pIMAGO™ is a universal phosphoprotein detection reagent developed by Tymora Analytical. This innovative antibody-free technology provides a highly efficient, safe, and unbiased method for phosphoprotein detection.The pIMAGO platform is based on water-soluble spherical nanopolymers (dendrimers) that are multifunctionally engineered to incorporate two essential components:

☉Reactive groups (e.g., Ti(IV) ions) that enable highly specific recognition of phosphate groups

☉Reporter groups (such as biotin or fluorescent tags) that generate measurable detection signals

This design allows researchers to perform sensitive and reliable phosphoprotein detection across a wide range of biological samples without relying on antibodies.

●Spin-Tip PolyMAC™ Technology for Phosphopeptide Enrichment Prior to Mass Spectrometry

PolyMAC™ technology utilizes metal-ion functionalized soluble nanopolymers that efficiently chelate phosphopeptides in a homogeneous aqueous environment.

Compared with traditional strategies based on solid-phase micro- or nano-particles, PolyMAC technology offers several advantages:

☉Excellent reproducibility

☉Exceptional selectivity

☉Rapid chelation kinetics

☉High recovery of phosphopeptides from complex mixtures

The Spin-Tip PolyMAC™ format further simplifies the enrichment workflow, enabling efficient phosphopeptide preparation prior to mass spectrometry analysis, which is essential for high-quality phosphoproteomics studies.

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