Founded in 2010, Advanced Electrophoresis Solutions Ltd. (AES) is a specialized developer of advanced technologies, carrier ampholytes, and workflow solutions for imaged capillary isoelectric focusing (iCIEF). The company focuses on serving the biopharmaceutical and protein chemistry industries through high-resolution iCIEF platforms, critical reagents, and customized support for complex biologics such as monoclonal antibodies, fusion proteins, and antibody-drug conjugates. AES also highlights its WCID-iCIEF and CEInfinite-related capabilities, along with in-house expertise in carrier ampholyte formulation, preparative iCIEF, and iCIEF-MS workflows for charge variant characterization.
■ Product Portfolio
Vicbio Biotechnology Co., Ltd. provides the full range of Advanced Electrophoresis Solutions products.
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●iCIEF Fractionation
AES provides iCIEF fractionation solutions for collecting iCIEF peaks for downstream applications such as peptide mapping and potency-related analysis. Its CEInfinite fractionation platform is designed to accelerate in-depth characterization of protein charge heterogeneity and support detailed follow-up studies during biologics development.
●iCIEF-MS Coupling
AES offers direct coupling of iCIEF with mass spectrometry for rapid intact mass analysis and characterization of critical quality attributes. The CEInfinite icIEF-MS Online system is designed to integrate seamlessly with mass spectrometers and provide faster feedback on protein charge isomers, post-translational modifications, and emerging biologic modalities.
●iCIEF Analytical Testing
AES supports high-performance analytical iCIEF workflows and highlights seamless method transfer from other iCIEF instruments. Its analytical systems are built to simplify protein characterization while maintaining reliable and consistent iCIEF operation for biopharmaceutical applications.
●AESlyte® Carrier Ampholytes
AESlyte® carrier ampholytes are developed to provide improved resolution, lot-to-lot consistency, and mass spectrometry compatibility. The product line includes multiple series and narrow-range options to support higher-resolution separations, method optimization, iCIEF fractionation, and iCIEF-MS workflows.
●CEInfinite Capillary Coatings
CEInfinite coatings include hydrophilic and hydrophobic options designed to ensure stability during iCIEF separation. These coatings are available for CEInfinite iCIEF cartridges and are intended to support next-generation iCIEF applications across different capillary formats.
●pI Markers
AES provides more than 40 pI marker options to improve the accuracy and consistency of isoelectric point measurements. These calibration standards are designed to support precise pI determination, gradient confirmation, and quality control in iCIEF assays.
●Custom Services
AES offers custom services including detailed pI profile analysis, expert protein peak collection, comprehensive iCIEF-MS coupling results, and customizable AESlyte® reagents. These services are intended to help optimize experimental protocols and reduce the burden of method development for protein characterization projects.
■ Product List
| Product name | Cat. # | Description |
| WCID 100 μL ID FC Cartridge R, 2/Pack | CP00201 | 100 μL ID, FC Coating, Regular |
| WCID 100 μL ID AD Cartridge R, 2/Pack | CP00301 | 100 μL ID, AD Coating, Regular |
| WCID 100 μL ID MC Cartridge R, 2/Pack | CP00501 | 100 μL ID, MC Coating, Regular |
| WCID 200 μL ID PA Cartridge HS, 2/Pack | CP00102 | 200 μL ID, PA Coating, High Sensitivity |
| WCID 200 μL ID FC Cartridge HS, 2/Pack | CP00202 | 200 μL ID, FC Coating, High Sensitivity |
| WCID 200 μL ID AD Cartridge HS, 2/Pack | CP00302 | 200 μL ID, AD Coating, High Sensitivity |
| WCID 200 μL ID AD Cartridge MS, 2/Pack | CP00303M | 200 μL ID, AD Coating, for MS Coupling,with Microfluidic Connector |
| WCID 200 μL ID MC Cartridge MS, 2/Pack | CP00503M | 200 μL ID, MC Coating, for MS Coupling,with Microfluidic Connector |
| WCID 320 μL ID AD Cartridge P, Regular, 2/Pack | CP00307 | 320 μL ID, AD Coating, Preparative |
| WCID 320 μL ID AD Cartridge P, 2/Pack | CP00307P | 320 μL ID, AD Coating, Preparative with Microfluidic Connector |
| WCID 320 μL ID MC Cartridge P, 2/Pack | CP00507P | 320 μL ID, MC Coating, Preparative with Microfluidic Connector |
| WCID 320 μL ID FC Cartridge P, Regular, 2/Pack | CP00207 | 320 μL ID, FC Coating, Preparative |
| WCID 320 μL ID FC Cartridge P, 2/Pack | CP00207P | 320 μL ID, FC Coating, Preparative with Microfluidic Connector |
| Starter Kit | 101052 | (CP00201) WCID FC Cartridge, 2 pkg (CS00801) Cartridge Storage Box, 1 pc (SV00801) 300uL Sample Vial, Snap Ring, 100/pack with Caps (1002xx) pI Marker, 2 pcs (101003) 1% Methyl Cellulose Solution, 1 pc (101005) 0.5% Methyl Cellulose Solution, 1 pc (101051) CIEF Suitability Mixture, 1 set (101023)AESlyte SH 2.5-5 (5 mL), 1 pc (101025)AESlyte SH 8-10.5 (5 mL), 1 pc (101026)AESlyte SH 3-10 (5 mL), 1 pc |
| Fractionation Starter Kit | 102052 | (CP00307P) WCID AD Cartridge, 1 pkg (CP00201) WCID FC Cartridge, 1pkg (CS00801) Cartridge Storage Box, 1 pc (SV00701) 2mL Sample Vial, 100/pack with cap (IN00701) 6mm Insert, 1 pkg (1002xx) pI Marker, 2 pcs (101003) 1% Methyl Cellulose Solution, 1 pc (101005) 0.5% Methyl Cellulose Solution, 1 pc (101051) CIEF Suitability Mixture, 1 set (101023)AESlyte SH 2.5-5 (5 mL), 1 pc (101025)AESlyte SH 8-10.5 (5 mL), 1 pc (101026)AESlyte SH 3-10 (5 mL), 1 pc |
| Fractionation Suitability Kit | 102051 | (102001) iCIEF Fractionation Extraction (FE) Solution, 5 mL, 1 pc (100216S) pI marker 7.05 Peptide, 100 μL, 1 pc (100220S) pI marker 7.90, 100 μL, 1 pc |
| icIEF/CEInfinite System Suitability Kit | 201051 | Hemoglobin Stock,50uL IEF Solution 8% pH-10 and two pI markers (4.22,9.46), 0.5 mL*10 |
| icIEF/CEInfinite Chemical Test Kit | 201052 | 1) Anolyte, 80 mM H3PO4 in 0.1% MC – 10 mL 2) Catholyte, 0.1% MC (NaOH added later) – 5 mL x 3 3) NaOH, 50% w/w (for Solution 2) – 500 μL 4) 0.5% Methyl Cellulose (MC) – 10 mL 5) Hemoglobin (Hb) Standard Stock (for Solution 6) – 30 μL 6) IEF solution 8% pH 3-10 AESlytes HR with pI markers 4.22 and 9.46 in 0.35% MC – 1 mL x 3 7) Deionized water in 1.5 mL vials x 2 8) 0.5% MC Conditioning Solution in 1.5 mL vial. |
| Nano Emitter Kit | NE01201 | Nano Emitter Kit |
| icIEF/CEInfinite TTM Solution Kit | 201053 | icIEF/CEInfinite TTM Solution Kit |
| Cartridge Storage Box | CS00801 | Cartridge Storage Box |
| 2 mL Sample Vial, 100/Pack with Cap | SV00701 | Clear Glass |
| 1.5 mL Sample Vial, Screw Thread, 100/Pack with Cap | SV00702 | Clear Glass |
| Sample Vial Lids | VL00701 | Sample Vial Lids |
| 300 μL Sample Vial, Snap Ring with Lids, 100/Pack | SV00801 | PP |
| AESlyte HR 5-8, 5 mL | 101014 | Store at 4 °C. |
| AESlyte HR 9-12, 5 mL | 101047 | Store at 4 °C. |
| AESlyte HR 8-9, 5 mL | 101045 | Store at 4 °C. |
| AESlyte HR 9.5-11, 5 mL | 101044 | Store at 4 °C. |
| AESlyte HR 9-10.5, 5 mL | 101043 | Store at 4 °C. |
| AESlyte HR 8.8-9.5, 5 mL | 101042 | Store at 4 °C. |
| AESlyte HR 4-6, 5 mL | 101040 | Store at 4 °C. |
| AESlyte HR 6.5-7.5, 5 mL | 101048 | Store at 4 °C. |
| AESlyte HR 7.5-8.5, 5 mL | 101075 | Store at 4 °C. |
| AESlyte HR 3-7, 5 mL | 101046 | Store at 4 °C. |
| AESlyte HR 4.2-4.9, 5 mL | 101020 | Store at 4 °C. |
| AESlyte HR 8.5-9.5, 5 mL | 101018 | Store at 4 °C. |
| AESlyte HR 7-9, 5 mL | 101011 | Store at 4 °C. |
| AESlyte HR 7-8, 5 mL | 101019 | Store at 4 °C. |
| AESlyte HR 6-8, 5 mL | 101041 | Store at 4 °C. |
| AESlyte HR 6-9, 5 mL | 101017 | Store at 4 °C. |
| AESlyte HR 3-10, 5 mL | 101016 | Store at 4 °C. |
| AESlyte HR 8-10.5, 5 mL | 101015 | Store at 4 °C. |
| AESlyte HR 2.5-5, 5 mL | 101013 | Store at 4 °C. |
| AESlyte HR 6-7, 5 mL | 101079 | Store at 4 °C. |
| AESlyte SH 2.5-5, 5 mL | 101023 | Store at 4 °C. |
| AESlyte SH 4-8, 5 mL | 101024 | Store at 4 °C. |
| AESlyte SH 8-10.5, 5 mL | 101025 | Store at 4 °C. |
| AESlyte SH 3-10, 5 mL | 101026 | Store at 4 °C. |
| AESlyte SH 6-9, 5 mL | 101027 | Store at 4 °C. |
| AESlyte SH 6-8, 5 mL | 101031 | Store at 4 °C. |
| AESlyte SH 7-8, 5 mL | 101029 | Store at 4 °C. |
| AESlyte SH 7-9, 5 mL | 101021 | Store at 4 °C. |
| AESlyte SH 5-8, 5 mL | 101022 | Store at 4 °C. |
| AESlyte SH 8.5-9.5, 5 mL | 101028 | Store at 4 °C. |
| AESlyte SH 8-9, 5 mL | 101032 | Store at 4 °C. |
| AESlyte SH 4-6, 5 mL | 101030 | Store at 4 °C. |
| AESlyte UH 3-10, 0.5 mL | 101066S | Store at 4 °C. |
| AESlyte UH 4-6, 5 mL | 101070 | Store at 4 °C. |
| AESlyte UH 4-6, 0.5 mL | 101070S | Store at 4 °C. |
| AESlyte UH 7-8, 0.5 mL | 101069S | Store at 4 °C. |
| AESlyte UH 7-9, 0.5 mL | 101071S | Store at 4 °C. |
| AESlyte UH 7-8, 5 mL | 101069 | Store at 4 °C. |
| AESlyte UH 7-9, 5 mL | 101071 | Store at 4 °C. |
| AESlyte UH 7.5-8.5, 5 mL | 101073 | Store at 4 °C. |
| AESlyte UH 3-10, 5 mL | 101066 | Store at 4 °C. |
| AESlyte UR 7-10, 5 mL | 101078 | Store at 4 °C. |
| AESlyte UH 6-8, 5 mL | 101077 | Store at 4 °C. |
| AESlyte UR 8.5-10, 5 mL | 101076 | Store at 4 °C. |
| AESlyte UH 5-8, 5 mL | 101062 | Store at 4 °C. |
| AESlyte UH 4-8, 5 mL | 101074 | Store at 4 °C. |
| AESlyte UH 4-10, 5 mL | 101072 | Store at 4 °C. |
| AESlyte UH 7-10, 5 mL | 101060 | Store at 4 °C. |
| AESlyte UH 7-10, 0.5 mL | 101060S | Store at 4 °C. |
| AESlyte UH 8.5-9.5, 0.5 mL | 101068S | Store at 4 °C. |
| AESlyte UH 8.5-9.5, 5 mL | 101068 | Store at 4 °C. |
| AESlyte UH 6-9, 5 mL | 101067 | Store at 4 °C. |
| AESlyte UH 8-10.5, 5 mL | 101065 | Store at 4 °C. |
| AESlyte UH 4-5, 5 mL | 101064 | Store at 4 °C. |
| AESlyte UH 4.2-4.9, 5 mL | 101084 | Store at 4 °C. |
| AESlyte UH 2.5-5, 5 mL | 101063 | Store at 4 °C. |
| Hemoglobin Stock Solution, 100 μL | 101001 | Store at 4 °C. |
| iCIEF FE Solution, 5 mL | 102001 | Store at 4 °C. |
| CIEF Suitability Mixture | 101051 | Store at 4 °C. |
| Formamide MS Grade, 5 mL | 103003 | Store at 4 °C. |
| NIST Standard (10 mg/mL), 50 μL | 103002 | Store at 4 °C. |
| IEF Solution (8%, pH 3-10), 25 mL | 101012 | Store at 4 °C. |
| Electrolyte Solutions (Anolyte, Catholyte), 100 mL x 2 | 101010 | Store at 4 °C. |
| 10 mM Iminodiacetic Acid Solution, 25 mL | 101009 | Store at 4 °C. |
| Catholyte Solution, 100 mL | 101008 | Store at 4 °C. |
| Anolyte, 100 mL | 101007 | Store at 4 °C. |
| 0.35% Methyl Cellulose Solution, 5 mL | 101099 | Store at 4 °C. |
| 0.5% Methyl Cellulose Solution, 100 mL | 101005 | Store at 4 °C. |
| 500 mM Arginine Solution, 500 μL | 101100 | Store at 4 °C. |
| 10 mM Arginine Solution, 25 mL | 101004 | Store at 4 °C. |
| 1% Methyl Cellulose Solution, 100 mL | 101003 | Store at 4 °C. |
| Condition Solution (0.35% MC + 4M Urea), 5 mL | 101002 | Store at 4 °C. |
| IEF Solution (4%, pH 3-10), 25 mL | 101000 | Store at 4 °C. |
| pI Marker 2.85, 250 μL | 100201 | Store at 4 °C. |
| pI Mixture, 250 μL | 100200 | Store at 4 °C. |
| pI Marker 7.03, 250 μL | 100231 | Store at 4 °C. |
| pI Marker 7.00 Peptide, 250 μL | 100215 | Store at 4 °C. |
| pI Marker 6.61, 250 μL | 100214 | Store at 4 °C. |
| pI Marker 6.14 Peptide, 250 μL | 100213 | Store at 4 °C. |
| pI Marker 5.91, 250 μL | 100212 | Store at 4 °C. |
| pI Marker 5.85 Peptide, 250 μL | 100211 | Store at 4 °C. |
| pI Marker 5.50, 250 μL | 100210 | Store at 4 °C. |
| pI Marker 5.28, 250 μL | 100235 | Store at 4 °C. |
| pI Marker 5.12, 250 μL | 100209 | Store at 4 °C. |
| pI Marker 4.50, 250 μL | 100240 | Store at 4 °C. |
| pI Marker 4.22, 250 μL | 100206 | Store at 4 °C. |
| pI Marker 4.14, 250 μL | 100205 | Store at 4 °C. |
| pI Marker 4.10 Peptide, 250 μL | 100204 | Store at 4 °C. |
| pI Marker 4.05, 250 μL | 100242 | Store at 4 °C. |
| pI Marker 3.38 Peptide, 250 μL | 100234 | Store at 4 °C. |
| pI Marker 3.21, 250 μL | 100202 | Store at 4 °C. |
| pI Marker 4.65, 250 μL | 100207 | Store at 4 °C. |
| pI Marker 9.33, 250 μL | 100225 | Store at 4 °C. |
| pI Marker 9.46, 250 μL | 100226 | Store at 4 °C. |
| pI Marker 9.50 Peptide, 250 μL | 100227 | Store at 4 °C. |
| pI Marker 9.77, 250 μL | 100228 | Store at 4 °C. |
| pI Marker 9.99 Peptide, 250 μL | 100236 | Store at 4 °C. |
| pI Marker 10.10, 250 μL | 100229 | Store at 4 °C. |
| pI Marker 10.17 Peptide, 250 μL | 100237 | Store at 4 °C. |
| pI Marker 10.45, 250 μL | 100230 | Store at 4 °C. |
| pI Marker 7.35, 250 μL | 100233 | Store at 4 °C. |
| pI Marker 9.22, 250 μL | 100224 | Store at 4 °C. |
| pI Marker 8.79 Peptide, 250 μL | 100223 | Store at 4 °C. |
| pI Marker 8.71, 250 μL | 100232 | Store at 4 °C. |
| pI Marker 8.40 Peptide, 250 μL | 100222 | Store at 4 °C. |
| pI Marker 8.18, 250 μL | 100221 | Store at 4 °C. |
| pI Marker 7.90, 250 μL | 100220 | Store at 4 °C. |
| pI Marker 7.65, 250 μL | 100219 | Store at 4 °C. |
| pI Marker 7.40, 250 μL | 100217 | Store at 4 °C. |
| pI Marker 7.05 Peptide, 250 μL | 100216 | Store at 4 °C. |
| pI Marker 9.86, 250 μL | 100239 | Store at 4 °C. |
| pI Marker 11.2, 250 μL | 100241 | Store at 4 °C. |
| pI Marker 7.46 Peptide, 250 μL | 100243 | Store at 4 °C. |
| Adjustable Bench for Instrument System | AB00601 | Adjustable bench for instrument system |
| Certified Syringe – 5 mL | SY00705 | Certified Syringe – 5 mL |
| 6 mm Insert, 300 µL, 100/Pack | IN00701 | 6 mm Insert, 300 µL, 100/Pack |
| External Power Supply | PS00501 | External Power Supply |
| Flush Tool | FT01201 | Flush Tool |
| Peek Connector (Connecting Syringe and Transfer Line) | PC00801 | Peek Connector (Connecting Syringe and Transfer Line) |
| Certified Syringe – 500 µL | SY00704 | Certified Syringe – 500 µL |
| Transfer Capillary, 40 cm, ID 100 µm | TC00701 | Transfer Capillary, 40 cm, ID 100 µm |
| Certified High Precision Pump – Standalone | SP00103 | Certified High Precision Pump – Standalone |
| LED UV Lamp Assembly | LA00901 | LED UV Lamp Assembly |
| Control Board | MO00201 | Control Board |
| Inlet Valve Tubing Kit (x5), Inlet Valve Tubing for Collection, 5 pcs, 5.7 cm | IT01201 | Inlet Valve Tubing Kit (x5), Inlet Valve Tubing for Collection, 5 pcs, 5.7 cm |
| Camera Assembly | CA00901 | Camera Assembly |
| Collection Tubing Kit (x5) | CT01201 | Collection Tubing Kit (x5) |
| High Voltage Module | HV00201 | High Voltage Module |
| CEPRO REV 001/2, Light Board | FP00201 | CEPRO REV 001/2, Light Board |
| Transfer Line Kit (Autosampler to Cartridge), Low Volume | TL01204 | Transfer Line Kit (Autosampler to Cartridge), Low Volume |
| Micro T Assembly Kit | MT01201 | Micro T Assembly Kit |
| Micro T | MT00801 | Micro T |
| Sleeve (x2) PEEK, 1/32 | SL00801 | Sleeve (x2) PEEK, 1/32 |
| Sleeve (x5) Teflon | SL00802 | Sleeve (x5) Teflon |
| Sleeve with Ferrule | SF00801 | Sleeve with Ferrule |
| Nut Fingertight and Ferrule PEEK (x2) | NF00801 | Nut Fingertight and Ferrule PEEK (x2) |
| MS Spray Needle, 75 µm | MN00601 | MS Spray Needle, 75 µm |
| MS Trigger Cable | TC00501 | MS Trigger Cable |
| Valve Plug | VP00701 | Valve Plug |
| Fibre Bundle | FB00401 | Fibre Bundle |
| Transfer Line Kit (Makeup Liquid Syringe Pump to Cartridge) | TL01205 | Transfer Line Kit (Makeup Liquid Syringe Pump to Cartridge) |
| Transfer Line Kit (Makeup Liquid Syringe Pump to Micro-T) | TL01203 | Transfer Line Kit (Makeup Liquid Syringe Pump to Micro-T) |
| Transfer Line Kit (Syringe Pump to Autosampler) | TL01202 | Transfer Line Kit (Syringe Pump to Autosampler) |
| Certified Syringe – 2.5 mL | SY00703 | Certified Syringe – 2.5 mL |
| AES Sample Needle | SN00601 | AES Sample Needle |
| AES Sample Needle Kit for Alias, Bottom Entry | SN01202 | AES Sample Needle Kit for Alias, Bottom Entry |
| CEPRO Sensor Board, 2048 Pixel | CS00201 | CEPRO Sensor Board, 2048 Pixel |
| Lens (Located Just Below Cartridge) | CL00701 | Lens (Located Just Below Cartridge) |
| Well Plug (Covering the Electrolyte Vessel) | WP00801 | Well Plug (Covering the Electrolyte Vessel) |
| Electrodes | EL00601 | Electrodes |
| Valve Rotor Seal 0.25 mm for PEEK Valve | VR00601 | Valve Rotor Seal 0.25 mm for PEEK Valve |
| Nut Hex and Ferrule PEEK (x2) | NH00801 | Nut Hex and Ferrule PEEK (x2) |
| Nut Flangeless and Ferrule | NF00802 | Nut Flangeless and Ferrule |
| Power Supply 24V | PW00101 | Power Supply 24V |
| Certified Syringe – 100 µL, with Metal Screw Connection | SY00701 | Certified Syringe – 100 µL, with Metal Screw Connection |
