TopoGEN is a research diagnostics company focused on high-quality topoisomerases and DNA gyrases for cancer research and related drug discovery applications. Its core offerings include drug screening kits for identifying topoisomerase-active compounds for cancer chemotherapy and antibacterial research, assay kits for detecting prokaryotic and eukaryotic topoisomerases, and a broad supporting portfolio of DNA substrates, antibodies, inhibitors, and repair-related tools. Public product information also shows dedicated service capabilities in cell-context topoisomerase screening and DNA repair assays.

■ Product Portfolio

Vicbio Biotechnology Co., Ltd. provides the full range of TopoGEN products.

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●Topo Enzymes

Includes topoisomerase enzymes such as human Topoisomerase I, mutant human Topoisomerase I, human Topoisomerase IIα, and E. coli Topoisomerase IV. TopoGEN and distributor product listings identify Topo Enzymes as a core product category.

●DNA Gyrases

Includes highly purified DNA gyrase products such as E. coli DNA gyrase and Staphylococcus aureus DNA gyrase for in vitro supercoiling assays and drug screening applications. Public product descriptions note that E. coli DNA gyrase is supplied as a holoenzyme and that S. aureus DNA gyrase is provided as a reconstituted active enzyme from GyrA and GyrB subunits.

●Topo Kits

Includes assay kits such as Topo I assay kits, Topo II assay kits, gyrase assay reagents, DNA unwinding kits, gyrase and relaxed DNA assay kits, and related topoisomerase detection tools. Official and distributor sources list Topo Kits as a main product category and show Topoisomerase I and II assay kits among the offerings.

●Drug Screening Kits

Designed to identify topoisomerase-targeting molecules for cancer chemotherapy and antibacterial applications. Public product information lists screening kits for Topo I, Topo II, Topo II based on kDNA, Topo IV, gyrase, and high-load Topo I inhibitor screening.

●Topo Antibodies

Includes topoisomerase antibodies as well as related antibody kits and protein molecular weight marker products for topoisomerase research workflows. TopoGEN’s official site includes both Topo I antibodies and antibody kits as dedicated product pages. 

●DNA Substrates

Provides DNA substrates for topoisomerase-related experiments, enabling studies of enzyme activity and mechanism on defined DNA sequences and structures. DNA Substrates are listed by TopoGEN distributors as one of the company’s standard product categories.

●TDP1 Products and TDP2 Products

Includes products related to TDP1 and TDP2, two enzymes involved in DNA repair, for use in mechanistic DNA repair research and related drug discovery studies. TDP1 Products and TDP2 Products are both listed as dedicated TopoGEN product categories. 

●Topo Related Drugs

Includes known topoisomerase inhibitors and related compounds for research controls, mechanistic studies, and screening applications. Public product listings identify Topo Related Drugs as one of the company’s product categories. 

●Stable Cell Lines for DNA Repair Assays

Provides stable cell-based reporter systems for DNA repair studies, supporting investigation of topoisomerase function in DNA repair and evaluation of compound effects in cellular contexts. Public TopoGEN product pages list multiple cell-based HR and NHEJ reporter systems. 

●Transfection-Based DNA Repair Assays

Includes transfection-based HR and NHEJ kits that use transient transfection to generate pools of cells carrying DNA repair reporters, enabling interrogation of the two major DNA repair pathways. Official product information highlights GFP readout, rapid workflow, and suitability for drug screening and imaging-based analysis.

■ Product List