AlphaThera focuses on simple, fast, and site-specific antibody labeling reagents for research applications. Its product portfolio covers fluorescent dyes and proteins, oligonucleotide conjugation reagents, enzyme conjugation reagents, epitope tags, click chemistry reagents, and biotin labeling solutions. The company’s core technology, oYo-Link®, is based on a low-molecular-weight (~8 kDa), high-affinity antibody-binding domain with a built-in photo-crosslinker in the Fc-binding site. Upon illumination with non-damaging black light, oYo-Link forms a covalent bond with the antibody, enabling site-specific labeling on the Fc region with up to two labels per antibody. This helps improve antibody performance, generate highly homogeneous conjugates, and support stable and reliable assay results. 

■ Product Portfolio

Vicbio Biotechnology Co., Ltd. provides the full range of AlphaThera products.

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●Fluorescent Labeling Reagents

Includes oYo-Link® SureLight® PE and oYo-Link® SureLight® APC for rapid, site-specific labeling of compatible antibodies with up to two fluorescent protein labels per antibody. Official product information also shows additional fluorescent protein options such as Far Red APC and PE-Cy7. These reagents require only 30 seconds of hands-on time, with conjugates ready in about 2 hours. 

●Enzyme Labeling Reagents

Includes oYo-Link® HRP for direct conjugation of horseradish peroxidase to primary antibodies for applications such as ELISA, IHC, and western blotting. Enzyme conjugation is listed by AlphaThera as one of the core oYo-Link product categories. 

●oYo-Link® Epitope Tags

Enables quick and easy labeling of antibodies with any of 10 epitope tags for multiplex immunoassays. This approach supports site-specific conjugation on the Fc region with 3× tandem repeat epitope tags, helping enable unique detection while minimizing cross-reactivity with other antibodies. Available epitope tags include His12, DYKDDDDK, V5, S, VSVg, NWS, S1, AU1, AU5, and HSV1. 

●oYo-Link® Click Chemistry and Chemical Conjugation

Includes oYo-Link® Azide, oYo-Link® DBCO, and oYo-Link® Tetrazine for click chemistry-based site-specific antibody labeling. This category is designed for flexible conjugation workflows and is part of AlphaThera’s broader site-specific labeling platform for attaching click chemistry tags, biotin, enzymes, oligonucleotides, and other functional groups. 

●Oligonucleotide Labeling Reagents

Includes oYo-Link® Oligo Custom for efficient site-specific labeling of compatible antibodies with custom oligonucleotides. Official information states that labeling can be performed with as little as 1 µg antibody and supports both single-stranded and double-stranded DNA, with oligonucleotide lengths of 80 bp or longer. These reagents are suitable for applications such as spatial transcriptomics and protein interaction studies. 

●LED Photo-Crosslinking Device

An LED device designed to provide the 365 nm, non-damaging long-wave UV light required for efficient site-specific labeling with all oYo-Link products. Official product information states that photocrosslinking is performed using 365 nm black light. 

●oYo-Link® Single-Biotin

Designed for site-specific labeling of compatible antibodies with up to two biotin labels per antibody for immobilization on streptavidin-coated surfaces. Site-specific immobilization helps ensure proper antibody orientation and can improve the sensitivity, stability, and lifetime of ELISA capture antibodies. The workflow is simple, requiring only mixing and photocrosslinking, with 30 seconds of hands-on time and about 2 hours total. 

●oYo-Link® His12 Tag

Designed for site-specific antibody immobilization on transition metal-coated surfaces such as Ni²⁺- or Co²⁺-coated surfaces. Proper antibody orientation through site-specific immobilization can improve the sensitivity, stability, and lifetime of capture antibodies and enhance antigen capture performance in ELISA workflows. 

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