ProteoGenix was founded in 2003 and specializes in services within the fields of molecular biology and immunology. The company has core expertise in polyclonal and monoclonal antibody development, recombinant protein expression and purification, peptide synthesis, and gene synthesis.ProteoGenix provides innovative solutions and technologies across six major areas: antibody engineering, bioprocess development, monoclonal and polyclonal antibody development, recombinant protein and antibody production, gene synthesis, and peptide synthesis.In addition to its custom services, ProteoGenix offers more than 200,000 products through its online store, including antibodies, proteins, ELISA kits, cell separation media, and nucleic acid purification kits. The company has also introduced several breakthrough innovations, such as the XtenCHO™ transient expression cell line, which demonstrates higher production efficiency than ExpiCHO™ systems.

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Vicbio Biotechnology Co., Ltd. provides the full range of proteogenix products. 

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1. Antibody Generation

ProteoGenix designs and synthesizes highly immunogenic antigens based on customer requirements.

•Hybridoma technology is used to generate monoclonal antibodies, ensuring high specificity and batch-to-batch consistency.

•Phage display technology enables the screening of high-affinity antibodies from large antibody libraries.

•Single B-cell screening allows direct isolation of antigen-specific antibodies from immunized animals or infected individuals, preserving the natural pairing and affinity of antibody chains.

2. Antibody Engineering

ProteoGenix provides comprehensive antibody engineering services, including:

•Antibody humanization, converting animal-derived antibodies into humanized antibodies to reduce immunogenicity and improve clinical safety.

•Affinity maturation, enhancing antibody binding affinity to target antigens through genetic engineering approaches.

•Antibody reformatting, including the design and production of complex antibody formats such as bispecific antibodies and antibody–drug conjugates (ADCs).

•Isotype and subclass switching, enabling modification of antibody isotypes or subclasses to optimize functional properties.

3. Antibody Production

Monoclonal antibodies are produced using recombinant DNA technology, ensuring high purity and product consistency.Stable cell lines can also be established for antibody production to improve manufacturing efficiency and yield.

4. Protein Production

Selection of appropriate expression systems based on protein characteristics, including E. coli, Bacillus subtilis, yeast, insect cells, and mammalian cells. Comprehensive services ranging from gene cloning, expression, and purification to characterization are also available according to client specifications.

5. Custom Peptide Synthesis

Peptide sequences are designed according to customer specifications, including length, amino acid composition, and modifications.Peptides are synthesized using advanced solid-phase or liquid-phase synthesis methods, followed by purification through high-performance liquid chromatography (HPLC).Quality and purity are verified through mass spectrometry analysis and amino acid analysis.

6. Custom Gene Synthesis

Gene sequences are designed according to customer requirements, including codon optimization and promoter selection.Genes are synthesized using chemical or enzymatic synthesis methods and cloned into appropriate expression vectors.Gene functionality and expression levels are verified through transfection and expression analysis.

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