InVivoMAb anti-mouse NK1.1

BE0036

Product Citations:

267

Clone:

PK136

Reactivities:

Mouse

Product Details

The PK136 monoclonal antibody reacts with mouse NK1.1 also known as CD161b/CD161c, KLRB1, NKR-P1A and Ly-55. NK1.1 is

 a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. NK1.1

 plays roles in NK cell activation and differentiation, IFN-γ production, cytotoxic granule release, and is thought to be involved 

in the generation of Th2 cells. NK1.1 is predominantly expressed as a disulfide-linked homodimer on NK cells however, it is also 

expressed on NK-T cells, a rare population of T lymphocytes. NK 1.1 is only expressed by C57BL/6, FVB/N, and NZB strains of

 mice and not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129 strains.

Isotype Mouse IgG2a, κ

Recommended Isotype Control(s) InVivoMAb mouse IgG2a isotype control, unknown specificity

Recommended Dilution Buffer InVivoPure pH 7.0 Dilution Buffer

Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.

Immunogen Mouse spleen and bone marrow cells enriched for NK1+ cells

Reported Applications in vivo NK cell depletion

Flow cytometry

Formulation PBS, pH 7.0

Contains no stabilizers or preservatives

Endotoxin <2EU/mg (<0.002EU/μg)

Determined by LAL gel clotting assay

Purity >95%

Determined by SDS-PAGE

Sterility 0.2 µm filtration

Production Purified from cell culture supernatant in an animal-free facility

Purification Protein A

RRID AB_1107737

Molecular Weight 150 kDa

Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.