品名：Seraseq® Cardiomyopathy Reference Material

货号：0740-0021 

品牌：SeraCare 

SPECIFICATIONS

Mutations included in the Seraseq Cardiomyopathy Reference Material 

Details

Seraseq Cardiomyopathy Reference Material addresses the lack of multiplexed, patient-like reference materials 

with an expert-designed product1 for targeted NGS assays focused on hypertrophic cardiomyopathy (HCM). 

This unique product combines ten actionable HCM mutations in a well-characterized genomic background 

and can be used for assay development, validation, and to support lab QC standardization. 

Key features include:  

Ten variants considered pathogenic or likely pathogenic for HCM in a single sample 

Mutation targets precisely quantitated with digital PCR 

Well-characterized GM24385 human genomic DNA as background wild-type material 

Manufactured in cGMP compliant and ISO 13485-certified facilities 

References: 

1. Emily M Kudalkar, Naif AM Almontarishi, Catherine Huang, Bharathi Anekella, Mark Bowser, Elizabeth Hynes, 

Russell Garlick, Birgit H. Funke. Multiplexed reference materials as controls for diagnostic next generation 

sequencing – a pilot investigating applications for hypertrophic cardiomyopathy, The Journal of Molecular 

Diagnostics. 

For research use only. Not for use in diagnostic procedures.

维百奥生物代理SeraCare对照及参比物质。

维百奥（北京）生物科技有限公司，自2018年与SeraCare（现隶属于LGC Clinical Diagnostics）合作以来，长期为中国客户

提供包括SeraSeq系列参比物质，领域包括肿瘤、生殖健康和遗传病。SeraCare研发和生产一系列临床参比物质，可以用于任何

研发阶段，以确保临床基因组学检测结果的准确性。

SeraCare参比物质涵盖的范围：

1）Next Generation Sequencing

2）Sanger Sequencing

3）Real-time PCR and digital PCR (dPCR)

4）Microarray

主要特点

1）Ready-to-use reference materials covering clinically-relevant variants and all variant types - SNVs, INDELS, CNVs, 

and RNA fusions

2）Highly multiplexed - provide significantly more data per NGS run, saving sequencing costs

3）Available in multiple formats to suite different workflow needs - purified DNA & RNA, ctDNA, encapsulated ctDNA 

in plasma, and FFPE

4）Manufactured in cGMP-compliant, ISO 13485-certified facilities

5）Stringent product release testing - all variants qualified by dPCR for allele frequencies or copy numbers