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产品名称 Recombinant Human IFN-gamma Protein 100ug(R&D Systems 285-IF/CF 现货特卖)
货号: 285-IF/CF 规格: 100ug
品牌: 热销产品 价格:
产品分类: 特价奥特莱斯专区 研究领域:
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产品描述


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维百奥生物库存现货,特价销售Recombinant Human IFN-gamma Protein 100ug

| 产品信息

品名:Recombinant Human IFN-gamma Protein

品牌:R&D Systems

货号:285-IF/CF

规格:100ug


产品属性

Alternate NamesIFG; IFI; IFNG; IFNgamma; IFN-gamma; Immune interferon; interferon gamma; interferon, gamma
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level<0.01 EU per 1 μg of the protein by the LAL method.
ActivityMeasured in anti-viral assays using HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. Meager, A. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 129. The ED50 for this effect is 0.15-0.75 ng/mL.
SourceE. coli-derived human IFN-gamma protein;Gln24-Gln166 with an N-terminal Met
Accession #CAA31639
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass16.9 kDa
SDS-PAGE17 kDa, reducing conditions


产品描述

Recombinant Human IFN-gamma (Catalog # 285-IF) has a molecular weight (MW) of 34.9 kDa as analyzed by SEC-MALS, suggesting that this protein is a homodimer.  MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine.It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (7).







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