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产品名称 Human IL-10 Recombinant Protein(PeproTech 200-10-50ug 现货特卖)
货号: 200-10-50ug 规格: 50ug
品牌: 热销产品 价格:
产品分类: 特价奥特莱斯专区 研究领域:
CAS编号: 分子量:
分子式: 别名:
储存条件: -20°C 运输条件: Ambient
货期: 应用:
说明书: 备注:
产品描述


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维百奥生物库存现货,特价销售Human IL-10 Recombinant Protein 50ug

| 产品信息

品名:Human IL-10 Recombinant Protein

品牌:Peprotech

货号:200-10-50ug

规格:50ug


产品属性

种属Human形式Lyophilized
Expression SystemE. coli纯化类型purified
分子量18.6 kDa内含物no preservative
内毒素浓度<1 EU/µg保存条件-20°C
偶联物Unconjugated运输条件Ambient
已发表种属Human, Mouse, Non-human primate, Pig, Virus
纯度≥ 98% by SDS-PAGE gel and HPLC analyses.
氨基酸序列MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
活性Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.


产品描述

Recombinant Human IL-10 is an 18.6 kDa protein of 161 amino acid residues.


| 耙标信息

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.







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