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产品名称 Recombinant Cynomolgus Cadherin-17 Protein (His Tag), HPLC-verified (义翘神州 90994-C08H 现货特卖)
货号: 90994-C08H 规格: 100 µg;1 mg
品牌: 热销产品 价格:
产品分类: 特价奥特莱斯专区 研究领域:
CAS编号: 分子量:
分子式: 别名:
储存条件: 运输条件:
货期: 应用:
说明书: 备注:
产品描述


90994-C08H.jpg

维百奥生物现货库存,特价销售Recombinant Cynomolgus Cadherin-17 Protein (His Tag), HPLC-verified !

| 产品信息

品名:Recombinant Cynomolgus Cadherin-17 Protein (His Tag), HPLC-verified

品牌:义翘神州

货号:90994-C08H

规格:100 µg;1 mg


产品属性

Accession#XP_005563762.2
表达宿主HEK293 Cells
种属Cynomolgus
预测 N 端Gln 23
内毒素< 1.0 EU per μg protein as determined by the LAL method.
蛋白构建A DNA sequence encoding the Cynomolgus CDH17 (XP_005563762.2) (Met 1-Thr784) was expressed with a polyhistidine tag at the C-terminus.
纯度≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
分子量The recombinant human CDH17 consists of 773 amino acids and predicts a molecular mass of 85.94 kDa. It migrates as an approximately 105.22 kDa band in SDS-PAGE under reducing conditions.
全称cadherin 17, LI cadherin (liver-intestine)
运输方式

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.

Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise

稳定性 & 储存条件Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.


|背景信息

Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.






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