A9518

Sigma-Aldrich

氨苄西林 钠盐

别名:

氨苄青霉素 钠盐

Empirical Formula (Hill Notation):

C16H18N3NaO4S

CAS号:

69-52-3

分子量:

371.39

Beilstein:

4119211

EC 号:

200-708-1

MDL编号:

MFCD00064313

PubChem化学物质编号:

24891463

NACRES:

NA.76

属性

形式

powder

质量水平

200

颜色

white to off-white

mp

215 °C (dec.) (lit.)

抗生素抗菌谱

Gram-negative bacteria

Gram-positive bacteria

application(s)

agriculture

作用机制

cell wall synthesis | interferes

储存温度

2-8°C

SMILES string

[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1

InChI key

KLOHDWPABZXLGI-YWUHCJSESA-M

说明

一般描述

Ampicillin sodium salt is a member of the extended-spectrum β-lactam family and a semisynthetic derivative of penicillin that functions as a broad-spectrum antibiotic. It is a β-lactam antibiotic that inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins (PBPs), thereby inhibiting peptidoglycan synthesis, a critical component of the bacterial cell wall. Ampicillin sodium salt is active against a wide range of Gram-positive and Gram-negative bacteria, including E. coli, β-lactam-sensitive VRE, vancomycin-resistant Enterococcus species, Staphylococcus aureus, and Streptococcus pneumoniae. It is commonly used in research laboratories to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, and the selection and maintenance of recombinant plasmids in E. coli.

应用

Ampicillin sodium salt has been used:

to select for ampicillin resistance in mutated and transformed cells

生化/生理作用

作用方式：该ß-内酰胺抗生素通过灭活位于细菌的细胞膜内表面的转肽酶从而抑制细菌细胞壁合成。

耐药性机制：ß-内酰胺酶切开氨苄青霉素的ß-内酰胺环,使其失去活性。

抗菌谱：包括革兰氏阳性菌(类似青霉素)和革兰氏阴性菌(类似四环素和氯霉素)。

特点和优势

High-quality antibiotic suitable for multiple research applications

Ideal for Cell Biology and Biochemical research.

注意

据报道，该产品在25°C、43%和81%相对湿度下可稳定6周。 另外的研究表明氨苄青霉素在溶液中的稳定性与pH、温度和缓冲液的性质有关。 当储存在pH值7以上时，它的活性很快就会丧失。 推荐最佳保存条件为2-8℃，pH 3.8-5，一周内其活性可保留90%。

制备说明

据报道，氨苄青霉素微溶于水，几乎不溶于酒精、氯仿、醚和固定油脂，但溶于稀酸或稀碱。 该溶液不应高压灭菌;原液应通过过滤消毒并冷冻保存，可稳定数月。

其他说明

将容器密封在干燥、通风良好的地方。储存类别(TRGS 510): 不可燃的固体